Weissella as an emerging probiotic candidate for IBD: current evidence, challenges, and future perspectives”

Next-generation probiotics and microbiome-based therapeutics highlighting Akkermansia muciniphila and Amuc_1100

Probiotics in Autoimmune Disease: Strain-specific Mechanisms and Therapeutic Perspectives

Evidence for potential synergy among probiotic combinations, contrast probiotic-based interventions with conventional immunosuppressive regimens in terms of their putative advantages and limitations, and examine the prospects for precision probiotic strategies alongside current challenges are discussed.

Novel Therapeutic Strategies for Active Crohn’s Disease: Targeting Pathobionts and Host–Microbe Interactions

Crohn’s disease (CD) is a chronic inflammatory disorder characterized by complex interactions among genetic susceptibility, environmental factors, dysregulated immune responses, and alterations of the intestinal microbiota. Although corticosteroids, immunomodulators, biologics, and advanced small-molecule therapies rem...

Adjunctive nutraceutical strategies in ulcerative colitis: From molecular pathways to clinical outcomes.

Ulcerative colitis is a chronic inflammatory disease of the large intestine, involving flare-ups and remissions. Its exact causes are unclear, but genetic susceptibility, immune dysregulation and environmental influences promote development. Conventional treatments have improved management, but some patients only respo...

Insight into Ulcerative Colitis and Associated Diarrhea: Exploring the Interplay of Cellular and Molecular Axis with Advancement in Treatments.

Ulcerative Colitis (UC)-associated diarrhea is a debilitating symptom of persistent intestinal inflammation that significantly reduces a patient's quality of life. Epithelial ion transport failure, tight junction remodeling, dysregulated mucus secretion, immunological overactivation, gut microbiota dysbiosis, and mitoc...

Bifidobacteria and Clostridioides difficile infection: review of emerging therapeutic perspectives.

Clostridioides difficile infection (CDI) remains a major cause of antibiotic-associated diarrhea and colitis, with a high rate of recurrence. Current CDI treatments rely largely on antibiotics that perpetuate dysbiosis or on microbiota-based interventions with limited accessibility, emphasizing the need to explore nove...