Engineering Heterotypic Biomolecular Condensates with Synthetic Peptides for Controlled Spatial Organization and Liquid-like Nature

Open access Jul 2026

Topology-Encoded Charge Polarity Governs Multiphase Organization in Intrinsically Disordered Protein Polymer Condensates.

Synthetic biomolecular condensates offer a route to engineer compartmentalized microenvironments with tunable physicochemical properties, yet design principles for controlling their internal organization remain limited. Here, we report a minimal two-component system based on thermoresponsive intrinsically disordered pr...

Julio Fernández-Fernández, V. Domínguez-Arca, Raúl Escribano et al. · Small · 0 citations

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Open access Sep 2026

Scaffold Affinity Tunes Biomolecular Condensate Function

It is found that affinity governs the phase boundary, resistance to chemical perturbation, and molecular mobility of condensates in vitro and in human cells and is shown to be a quantitative determinant of condensate phase behavior, internal dynamics and biochemical output.

Andres Reyna, Madyson O. Briggs, Alexander F. Russell et al. · bioRxiv · 0 citations

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Open access Jul 2026

Programmable Multiphasic Condensates Formed via Evaporation–Induced Phase Separation of Minimal Peptide Model

Biomolecular self‐assembly is ubiquitous in nature, encompassing both ordered and disordered structures to create sophisticated superstructures essential for complex biological functions. Protein and peptide condensates formed via liquid–liquid phase separation (LLPS) are characterize by disordered assembly, gaining si...

Rohit Kumar, Sukantha Dey, P. Rajput et al. · Advances in Materials · 1 citation

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2026

Synthetic Biomolecular Condensates: Design Principles and Applications.

This chapter describes synthetic gene circuit-based methods for applying synthetic condensates in E. coli to regulate transcription and translation and demonstrates how engineering synthetic condensates offers a new layer of cellular control for synthetic biology.

Yuefeng Ma, Leshan Yang, Yifan Dai · Methods in molecular biology · 0 citations

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Open access Jul 2026

Programming Multidomain Peptides With Molecular Frustration Into Biomolecular Condensates

The discovery of biomolecular condensates, driven by liquid–liquid phase separation of intrinsically disordered proteins has significant impacts on both fundamental and applied science and engineering. Although most studies on biomolecular condensates focus on intrinsically disordered structures, research on the role o...

Debdatta Das, Jenny N Nguyen, Navneet Sahoo et al. · Small · 0 citations

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Open access Aug 2026

Sequence-dependent molecular asymmetry and architecture define electric potential profiles of biomolecular condensates

Biomolecular condensates, which regulate diverse cellular processes, exhibit distinct electric potential profiles. This potential gradient between the dilute and the dense phases serves as the underlying driving force mediating the unique microenvironment and electrochemical activity of condensates. However, the molecu...

Fangke Chen, Runchen Xia, Yi-Fan Dai et al. · bioRxiv · 0 citations

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