Jul 2026· Current Opinion in Structural Biology· Vol 99, pp.
103309
· 0 citations· 47 references
Medicine
TL;DR
This review discusses how features of protein sequence, such as amino acid composition, interaction motifs, and post-translational modifications, influence condensate aging and highlights how interactions with RNA and lipid membranes modulate condensate behavior by altering interaction networks and interfacial properties.
Abstract
Biomolecular condensates play key roles in the cell by organizing and regulating important biochemical processes, including transcriptional regulation, RNA metabolism, ribosome biogenesis, and stress responses. While these assemblies are typically dynamic, some can undergo time-dependent aging into solid assemblies, which in certain cases has been linked to pathologies including neurodegenerative diseases. In this review, we focus on the mechanisms that drive condensate aging. In particular, we discuss how features of protein sequence, such as amino acid composition, interaction motifs, and post-translational modifications, influence condensate aging. We further highlight how interactions with RNA and lipid membranes modulate condensate behavior by altering interaction networks and interfacial properties.
This review summarizes how individual RNA modifications and their associated proteins regulate the formation and function of BMCs such as stress granules, P-bodies, nuclear bodies and disease-linked condensates in cancer and neurodegeneration.
Y. Sprecher, M. Sevilla-Sharon, S. Moshitch-Moshkovitz· Genes· 0 citations
G3BP1 is a central scaffold of stress granules (SGs). Upon cellular stress, G3BP1 forms complex coacervates with translationally repressed mRNAs and recruits multiple RNA-binding proteins to form reversible biomolecular condensates. Persistent SGs are linked to age-dependent dynamical arrest and impaired disassembly. H...
The fundamental molecular mechanisms driving LLPS are examined, the current evidence for LLPS in macromolecular organization and cellular regulation in fungi is evaluated, and the tools employed to study this phenomenon are outlined.
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A review of the latest breakthroughs in the structural classification of G4s reveals the multifaceted physiological and pathological functions of G4‐driven condensates, including chromatin organization, assembly of stress granules and paraspeckles, abnormal transcriptional activation, telomere maintenance, neurodegener...
Wenmeng Wang, Qingqing Xu, Yuxin Zhang et al.· Advancement of science· 0 citations
The current literature is summarized and biomolecular condensates are described as key regulators of protein misfolding and aggregation and the importance of the local milieu in determining aggregation outcomes is highlighted.
Emre Pekbilir, Dorothee Dormann· Current Opinion in Structura...· 0 citations
This work performs equilibrium and non-equilibrium residue-resolution molecular dynamics simulations to determine how RNA and heterotypic protein interactions regulate the pathological hardening of multicomponent FUS-containing condensates inspired by stress-granule composition.
Eduardo Pedraza, Óscar Rebato, A. Feito et al.· bioRxiv· 0 citations
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