Neuroprotective Role of E3 Ubiquitin Ligase TRIM2 in Parkinson's Disease: Attenuation of Oxidative Stress and Apoptosis via Promoting ELAVL1 Ubiquitination
A downregulated TRIM2 is identified in the substantia nigra pars compacta of PD rats based on label‐free proteomics, and the impact of TRIM2 on PD is unknown.
Abstract
Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons, where oxidative stress and neuronal apoptosis are key pathogenic events. In this study, we identified a downregulated TRIM2 in the substantia nigra pars compacta (SNc) of PD rats based on label‐free proteomics. However, the impact of TRIM2 on PD is unknown.
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