ITCH‐Mediated Ubiquitination and Degradation of THBS1: A Key Mechanism for Enhancing Mitochondrial Biogenesis and Alleviating Mouse Skeletal Muscle Atrophy
Aug 2026· Acta Physiologica· Vol 242· 0 citations· 57 references
Medicine
TL;DR
Itchy E3 ubiquitin‐protein ligase modulates mitochondria, and thrombospondin 1 positively regulates muscle atrophy, but their roles in muscle atrophy are unclear.
Abstract
Skeletal muscle atrophy is tightly associated with maladaptive alterations in mitochondrial function and morphology. Itchy E3 ubiquitin‐protein ligase (ITCH) modulates mitochondria, and thrombospondin 1 (THBS1) positively regulates muscle atrophy, but their roles in muscle atrophy are unclear.
This study investigated the role of Sptbn2 in post‐stroke cognitive impairment (PSCI) and the mechanisms regarding m6A and found that m6A facilitates functional recovery following ischemic stroke.
A downregulated TRIM2 is identified in the substantia nigra pars compacta of PD rats based on label‐free proteomics, and the impact of TRIM2 on PD is unknown.
This study explored whether intermittent hypoxia modulates injured dorsal root ganglion (DRG) neuron regeneration via lactate‐mediated mechanisms via lactate‐mediated mechanisms.
S. An, Jing-Fei Shi, Jiang Huang et al.· Journal of the peripheral ne...· 0 citations
It is demonstrated that allosteric modulation of the mitochondrial protein Miro1 can selectively reprogram mitochondrial stress signaling and can produce distinct responses in disease-relevant cell types, despite acting within a broadly conserved stress pathway.
Layla Drwesh, Julia C Fitzgerald· Cell Chemical Biology· 0 citations
PUM2 expression increases upon aging and this facilitates the capture/trapping of Mff mRNA, either alone or in association with other RNA-binding proteins (RBPs) in Ribonucleoprotein particles (RNP).
