Jul 2026· Journal of Evaluation In Clinical Practice· Vol 32· 0 citations· 31 references
Medicine
TL;DR
The proposed ontology addresses key ambiguities within WHO‐FIC, including the relationship between Activity and Participation and the perceived hierarchical privileging of diagnosis, and offers a more coherent and cognitively usable framework while respecting limits on human reasoning and managing the complexity‐coherence trade‐off.
Abstract
ABSTRACT Background Clinical reasoning in contemporary practice often involves ill‐structured, poorly defined problems that span the biopsychosocial domain and require reasoning under high relational complexity. Despite sustained scholarly attention to clinical reasoning, few models are both theoretically grounded and usable for clinicians who face this complexity. At the same time, the World Health Organization Family of International Classifications (WHO‐FIC) offers a rich but complex ontology that was not designed primarily to support clinical reasoning in practice. Aim To develop a two‐stage WHO‐FIC‐based ontological model of clinical reasoning that is conceptually coherent yet remains cognitively tractable in the face of complexity. Methods A conceptual analysis was undertaken. It integrated three strands: (1) WHO‐FIC classification theory, including recent work on harmonisation; (2) empirical and theoretical literature on clinical reasoning; and (3) cognitive theories of bounded rationality, fast‐and‐frugal heuristics, relational complexity, and framing. These strands were used to derive design constraints for a clinically usable ontology. They were then synthesised into a two‐stage, graph‐based model designed to manage the complexity‐coherence trade‐off in clinical reasoning. Results Stage 1 introduces a parsimonious triad—Body, Activity, and Environment—represented as a complete three‐node graph with bidirectional relations. This triad provides an etiologically neutral and cognitively economical starting point for framing complex clinical problems. Stage 2 introduces three emergent constructs—Health Condition, Participation, and Intervention—derived compositionally from Stage 1 relations and aligned with ICD‐11, ICF, and ICHI, respectively. The model supports iterative movement between stages through composition and decomposition. It incrementally increases complexity while keeping relational load within cognitively feasible bounds and preserves the value of diagnosis while reducing its tendency to dominate problem framing. A worked case illustrates how the ontology supports reasoning about complex, time‐dependent problems through repeated movement between stages. Conclusions The proposed ontology addresses key ambiguities within WHO‐FIC, including the relationship between Activity and Participation and the perceived hierarchical privileging of diagnosis. It offers a more coherent and cognitively usable framework while respecting limits on human reasoning and managing the complexity‐coherence trade‐off. The model provides a theoretically grounded heuristic scaffold for clinicians and educators who work with complexity. It also contributes to clinical reasoning literature by emphasising reasoning about concepts, not only cases, with implications for interprofessional education and practice.
PhysioMap connects ontology-grounded physiological content to interventional prediction and abduction under incomplete quantitative knowledge, and connects ontology-grounded physiological content to interventional prediction and abduction under incomplete quantitative knowledge.
R. Hoehndorf, Paul N. Schofield, G. Gkoutos· bioRxiv· 0 citations
A semantic model for scientific evidence with three core classes is introduced, specialize it for genetics, align it structurally to FHIR Evidence with a SEPIO-anchored credibility decomposition, and attach a compact dimensional vocabulary whose conditional-activation rules are validated by a SHACL schema for the imple...
The study explores the role of ontology in healthcare by surveying numerous research articles to provide a comprehensive overview of its applications, benefits, and challenges, and identifies prevalent issues, such as limited standardization, difficulty in updating ontologies to reflect the latest medical insights, and...
U. Priyadharshini, R. Vijayan· Frontiers in Artificial Inte...· 0 citations
A single LLM verifier lacks sufficient reliability to serve as a stand-alone judge of clinical reasoning at scale, and that structured human oversight remains essential.
Hyunjung Byun, Dahyoun Lee, Munyoung Jung et al.· Journal of medical systems· 1 citation· ⚡1
Automated harmonization of clinical trial condition data across heterogeneous registries is feasible and supports the use of a common ICD-10 framework for cross-registry analyses, and indicates that LLMs can support analyses of the distribution of health conditions investigated in clinical trials in Germany.
R. Ndabashinze, D. Franzen, E. Kozuch et al.· medRxiv· 0 citations
LabBridge demonstrates that embedding LLMs with an ontology-aware, agent-coordinated architecture enables effective standardization of laboratory data, and offers a practical pathway toward scalable, auditable semantic interoperability in health care ecosystems.
Lijuan Wu, Jin-Xing Huang, Hong-Nian Wang et al.· Journal of Medical Internet...· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.