Aug 2026· Zeitschrift für Induktive Abstammungs- und Vererbungslehre· Vol 301· 0 citations· 62 references
Medicine
TL;DR
Results provide experimental support for targeting the PI3K/AKT/mTOR axis as a potential therapeutic strategy in cervical cancer through functional and mechanistic link between recurrent PIK3CA-E545K-MUT and aggressive tumor behavior in cervical cancer via AKT/mTOR pathway activation.
In vivo xenograft and experimental metastasis models validated that ESM1 depletion significantly impaired tumor growth and lung metastasis while increasing ID3 expression, identifying the ESM1/DNMT3A/ID3 axis as a novel epigenetic driver of cervical cancer and a potential therapeutic target.
Chen-Lin Yu, Chia-Liang Lin, Hsiang-Lin Lee et al.· Cell Death Discovery· 0 citations
It is suggested that TP53AIP1 may serve as a potential prognostic biomarker and tumor-suppressive candidate in breast cancer, with its effects at least partly associated with MAPK pathway attenuation.
Meihai Deng, Xueting Wu, J. Bai et al.· Discover Oncology· 0 citations
Mechanistic and in vivo evidence linking EI24 to AKT pathway regulation is provided and supports further investigation of EI24-based approaches as potential therapeutic strategies for AKT-driven TNBC.
T. Nam, You Min Kim, Hye Mi Park et al.· Frontiers in Oncology· 0 citations
This study reveals post-transcriptional regulation of METTL3 by miR-338-5p by confirming a functional miR-338-5p/METTL3/m6A axis in TNBC and targeting this distinct regulatory axis represents a promising therapeutic strategy for TNBC.
Wen-Jia Chen, Ya Xu, Yang-Zheng Lan et al.· Clinical and Translational O...· 0 citations
Elevated MXRA5 expression exhibited a positive correlation with advanced lymph node metastasis and impaired clinical prognosis, and its potential as a valuable prognostic biomarker and therapeutic target for managing metastatic disease is revealed.
Jian Wang, Jie Tang, Yaoxin Wang· Korean Journal of Physiology...· 0 citations
The high expression of E5—associated with immune evasion—combined with reduced mTOR expression suggests that HPV16 status may influence therapeutic response in breast cancer patients, reinforcing the importance of further studies investigating HPV activity in breast tumors to better understand its biological and clinic...
Beatriz Eda de Oliveira Isídio, Pedro Henrique Bezerra Fontes, Gabriel Rômulo Parente da Silva et al.· Exploration of Targeted Anti...· 1 citation
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