Tunable AMPA receptor function via recurrent evolution of heterotetramers

Abstract

AMPA receptors are glutamate receptors specific to bilaterian animals with complex nervous systems. Wang et al. investigated the biophysical function, pharmacology, and kinetics of AMPA receptors from diverse bilaterians, uncovering convergent evolution on functional hallmarks, such as heteromerization and channel properties, throughout the AMPA receptor family.