From xanthine oxidase inhibition to inflammasome regulation: exploring the potential role of allopurinol in TXNIP–NLRP3 signaling and pyroptosis in diabetes

Targeting the P2X7–NLRP3 Inflammasome Axis in Obesity: Circadian Regulation of Metabolic Inflammation and Disease Progression

This study signifies the mechanisms underlying circadian regulation of the P2X7–NLRP3 axis, its tissue-specific roles in obesity, and available preclinical and clinical evidence, and further review innovative therapeutics like inflammatory inhibiting targets including inflammasome inhibitors, P2X7 antagonists and chron...

Metformin Alleviates High Glucose‐Induced Pyroptosis and Inflammatory Responses in HK‐2 Cells via SIRT1‐Associated Regulation of the TXNIP/NLRP3 Pathway

Pyroptosis, a Gasdermin‐dependent inflammatory form of programmed cell death, has been implicated in DKD progression and metformin has shown renoprotective effects in DKD; however, the underlying mechanisms remain unclear.

Targeting Ferroptosis, Pyroptosis, and NRF2 Signaling with Dietary Polyphenols in Diabetic Microvascular Complications: An Integrative Review

The proposed ferroptosis–pyroptosis–NRF2 network should be viewed as a biologically plausible integrative framework rather than a clinically validated linear pathway.

Hyper-O-GlcNAcylation destabilizes ARC to unleash NLRP3-mediated pyroptosis in diabetic cardiomyopathy.

Modulating the NLRP3/IL-1β Axis in Age-Related Atherosclerosis: Natural Products, Molecular Mechanisms, and Translational Perspectives—A Narrative Review

Atherosclerosis is an age-related immune-metabolic disease in which lipid retention, endothelial dysfunction, innate immune activation, and vascular remodeling interact over decades. In older adults, inflammaging, mitochondrial dysfunction, defective autophagy/mitophagy, and cellular senescence may lower the threshold...

Role of the cGAS-STING signaling pathway in diabetes mellitus and its complications: from mechanisms to therapeutics

A novel perspective on the inflammatory mechanisms underlying diabetes mellitus and its complications is provided, thereby establishing a theoretical foundation for the development of therapeutic strategies centered on modulating the cGAS-STING pathway.