Metformin Alleviates High Glucose‐Induced Pyroptosis and Inflammatory Responses in HK‐2 Cells via SIRT1‐Associated Regulation of the TXNIP/NLRP3 Pathway
Aug 2026· Diabetes, obesity and metabolism· Vol 28, pp. 10343 - 10369· 0 citations· 41 references
Medicine
TL;DR
Pyroptosis, a Gasdermin‐dependent inflammatory form of programmed cell death, has been implicated in DKD progression and metformin has shown renoprotective effects in DKD; however, the underlying mechanisms remain unclear.
Abstract
Diabetic kidney disease (DKD) is a major cause of renal failure and end‐stage renal disease. Pyroptosis, a Gasdermin‐dependent inflammatory form of programmed cell death, has been implicated in DKD progression. Metformin has shown renoprotective effects in DKD; however, the underlying mechanisms remain unclear.
Insulin resistance (IR) is a key pathological basis of metabolic diseases. Dityrosine (Dityr), a characteristic protein oxidation product commonly present in over-processed foods, can induce IR by disrupting metabolic homeostasis....
Jia Chen, Jing-Nan Zhu, Qin Jia et al.· Food & Function· 0 citations
Pyroptosis‐related signaling contributes to lung adenocarcinoma (LUAD) progression and prognosis. Apigenin (AP) has anti‐inflammatory and cytoprotective properties, but its effects on pyroptosis‐associated signaling in injured LUAD cells remain unclear.
Kai-Rui Zhu, Yu-Long Mu, Zhen-Guo Su et al.· Thoracic Cancer· 0 citations
Diabetic kidney disease (DKD) is one of the main causes of kidney failure worldwide. Interestingly, patients affected by DKD are characterised by a low abundance of gut bacteria producing short fatty acids including butyrate, which is suggested to play a role in the decline of renal function. Consequently, we aimed to...
M. Nicese, A. Koudijs, Reshma A. Lalai et al.· Diabetes, obesity and metabo...· 0 citations
Diabetes mellitus is commonly featured with cardiac microvascular dysfunction and chronic low‐grade inflammation, contributing to the progression of diabetic cardiomyopathy (DCM). Finerenone confers cardio‐renal protection in diabetic settings, yet its underlying mechanisms remain incompletely defined.
Su Li, He-Xi Zhang, Muyin Liu et al.· Acta Physiologica· 0 citations
The role of AS160 in regulating mitochondrial homeostasis and insulin secretion in pancreatic β‐cells is investigated and the underlying molecular mechanism involving its interaction with HSPA8 and activation of PINK1‐Parkin‐mediated mitophagy is elucidated.
Wenli Chen, Yanting Lu, Xiang-xiang Liu et al.· Acta Physiologica· 1 citation
Aberrant activation of dynamin‐related protein 1 (Drp1) promotes excessive mitochondrial reactive oxygen species (mtROS) production; however, whether the Drp1‐mtROS pathway mediates the renoprotective effects of aerobic exercise remains unclear.
Hui-Qian Ren, Hao-Feng Sun, Zhe-Ying Ma et al.· Acta Physiologica· 0 citations
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