Selective Cytotoxic and Redox-Associated Effects of Plant-Derived Terpenoids in Human Glioblastoma Cells

Comparative Evaluation of Cytotoxic, Genotoxic, and Apoptotic Effects of Naringenin and Naringenin-Oxime in Colorectal Cancer Cells.

Colorectal cancer (CRC) remains a major global health concern, accounting for 9.6% of all cancer cases and 9.3% of cancer-related deaths. Natural compounds with anticancer properties have gained increasing interest due to their potential for reduced toxicity. This study investigated the cytotoxic, genotoxic, and apopto...

NaHS inhibits cell proliferation by enhancing oxidative stress and apoptosis in HCT116 cells

NaHS exerts potent antiproliferative effects in colorectal cancer cells by inducing oxidative stress–mediated apoptosis and inhibiting key survival and inflammatory signaling pathways.

ONC212 Induces Ferroptosis-Associated Cell Death in Glioblastoma Cells

Preliminary evidence suggests that ONC212 induces ferroptosis-associated cell death through modulation of oxidative stress and ferroptosis‑associated gene expression is provided, and Targeting ferroptosis with ONC212 may represent a promising therapeutic strategy for GBM.

4-Chloro-7-Nitrobenzofurazan induces ROS-mediated p53 dependent apoptosis in human fibrosarcoma cells

Three Thiol-Reactive Reagents drive Synergistic Lethality in Glioblastoma cells

It is suggested that combining multiple Cys-associated redox targets is a putative therapeutic strategy for GBM, which offers a promising approach for improving treatment outcomes in GBM and other malignancies.

Synergistic In Vitro Effects of Minor Phytocannabinoids and Melatonin Combinations Against Human Glioblastoma Cells

This co-treatment emerges as a promising approach to potentiate TMZ efficacy, offering a novel and potentially effective therapeutic strategy to counter GBM resilience.