This study provides the first single-cell transcriptomic atlas of goat ovarian development, delineating dynamic gene expression patterns and cellular interactions during primordial follicle pool establishment, and advance understanding of conserved and species-specific mechanisms governing female reproductive lifespan in mammals.
A single-cell RNA-sequencing atlas of the bovine fetal ovary at four gestational timepoints is presented, capturing the progression of PGCs through commitment, meiotic entry, and early oocyte growth and providing a developmental roadmap for bovine oogenesis at the single-cell resolution that advances fundamental unders...
C. Guiltinan, R. Botigelli, R. Arcanjo et al.· bioRxiv· 0 citations
Integrated dual-omics analysis provided a high-resolution characterization of cell type-specific transcriptional and proteomic changes in single oocytes and their surrounding mini-bulk GCs, providing mechanistic insights into oocyte development and follicle growth.
Hong-Chao Li, Xinshuai Zhang, Huimin Kang et al.· Genomics, Proteomics & Bioin...· 0 citations
It is demonstrated that miR-187 acts as a previously unrecognized regulator of early folliculogenesis and female reproductive capacity in medaka, expanding the repertoire of miRNAs with essential in vivo roles in teleost oogenesis and female fecundity.
Marlène Davilma, Stéphanie Gay, Manon Thomas et al.· Scientific Reports· 0 citations
Reconstructing a map of intrafollicular interactions provides novel insights and important clues for understanding cellular and molecular mechanisms that fine-tune antral folliculogenesis and offers a roadmap for predicting candidate factors that can be used for optimizing mammalian in vitro embryo production systems.
Zhaochen Wang, Zhenni Zhang, Ya-Wen Tang et al.· Journal of Animal Science an...· 0 citations
The EV–mediated mRNA-miRNA signaling occurring during folliculogenesis in the southern white rhinoceros (SWR) may offer critical insights into physiological reproductive conditions that contribute to oocyte maturation, ultimately informing the development of novel reproductive strategies to enhance ART outcomes in this...
Ahmed Gad, K. Klohonatz, N. Menjivar et al.· Frontiers in Cell and Develo...· 0 citations
It is demonstrated how fundamental knowledge of the oocyte microenvironment can be harnessed to design cellular technologies for clinical applications and enhances the efficacy of assisted reproductive technologies (ART).
T. S. Arkhipova, A. V. Serbina, A. Saifitdinova· Cell and Tissue Biology· 0 citations
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