An evolutionarily ancient regulatory module is uncovered that shapes the molecular organization and function of IE KEAs, advancing the understanding of plastid ion and pH homeostasis and plastid ribosome integrity.
These findings identify the cytosolic ENGase as a key component of fungal proteostasis and suggest that N. crassa activates alternative compensatory mechanisms to maintain protein quality control when canonical deglycosylation pathways are impaired.
A. Samaras, Tanim Jabid Hossain, Magnus Karlsson et al.· The FEBS Journal· 0 citations
The findings extend the mechanistic understanding of Rab7 beyond its catalytic pocket and establish the AflRab7 C-terminal IDR as a critical regulatory element that couples vacuolar dynamics to A. flavus development and aflatoxin biosynthesis, highlighting a tractable target for mitigating fungal toxigenic potential.
Yu Wang, Chunlan Xie, Xiaoliu Ming et al.· International Journal of Bio...· 0 citations
How the recently gained knowledge about PHO1 and XPR1 structure and its cell biology is shaping views about how these proteins contribute to Pi homeostasis at the cellular and organismal levels is highlighted.
Yves Poirier, María Victoria Aparicio Chacon· Plant Physiology· 0 citations
Mycobacteria possess a complex double-membrane cell envelope critical for survival and pathogenesis. Proper assembly of this architecture requires the biosynthesis and transport of major components, including arabinogalactan (AG) polysaccharides and mycolic acids (MAs), but how these processes are effectively coordinat...
These findings unravel the multifaceted and crucial functions of OsFtsH1 in orchestrating chloroplast development, photosynthetic machinery homeostasis, and stress response in rice.