Property guidance for protein sequence generative models with ProteinGuide.

Junhao Xiong Ishan Gaur Maria Lukarska Hunter M. Nisonoff L. Oltrogge David F. Savage Jennifer Listgarten

Jul 2026 · Nature Biotechnology · 1 citation · 49 references

Medicine

TL;DR

ProteinGuide is applied jointly with wet-lab data generation to increase the editing activity of an adenine base editor in vivo, resulting in a base editor with higher editing efficiency than was previously achieved using seven rounds of directed evolution.

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