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Pathway‐Specific Polygenic Risk Score and Risk of Hyperglycaemic Progression in Patients With Type 2 Diabetes

Sylvia Liu Hui-Li Zheng Jia Le Ivan Tan K. Ang D. Zheng R. L. Gurung Su-Chi Lim Jian-Jun Liu
Sep 2026 · Diabetes, obesity and metabolism · Vol 28, pp. 10827 - 10834 · 0 citations · 24 references
Medicine

Abstract

Pathway‐specific polygenic risk scores (psPRS) provide insights into the heterogeneity of type 2 diabetes. We aim to study whether psPRS for beta cell dysfunction, obesity and metabolic syndrome associate with risk of hyperglycaemic progression in Southeast Asian patients with type 2 diabetes.

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