Bioactive electrospun chitosan/magnesium-doped hydroxyapatite nanocomposite scaffold co-loaded with icariin, lithium chloride and naringin for enhanced osteogenesis, antibacterial activity and bone regeneration in vitro and in vivo
The bioactive chitosan/Mg-HAp nanocomposite scaffold effectively promotes bone regeneration by enhancing osteogenic signaling pathways and exhibits strong potential for bone tissue engineering applications.
Chitosan/Mg‐HAp scaffolds enriched with icariin, lithium chloride, and naringin exhibit an advantageous combination of structural, mechanical, biological, and antimicrobial properties, and effectively promote bone regeneration without the need for expensive recombinant growth factors, highlighting their potential as ad...
Sahar Hefzollesan, H. Musayeva, Hamed Aghazadeh et al.· Journal of Applied Polymer S...· 0 citations
Findings reveal synergistic osteoregenerative and antibacterial activity, suggesting that the nanofibrous membrane may serve as a potential material for osteochondral tissue engineering.
Sadaf Ameen, Aneela Anwar, Javeria Zahid et al.· European Journal of Pharmace...· 0 citations
It is demonstrated that ionic doping confers distinct and complementary bioactivities to monetite, pro-angiogenic/migratory Co2+, and osteogenic/matrix-synthetic Mg2+, and that chitosan hydrogels represent an injectable vehicle that amplifies bioactive signaling upon direct cell contact, thus offering a versatile and i...
G. S. de Almeida, Matheus Luquirini Santos, Maria Gabriela Jacheto Carra et al.· ACS Biomaterials Science & E...· 0 citations
Findings support cation-engineered LDH hydrogels as promising injectable biomaterials, although pathway inhibition, protein-level validation, ion-release profiling, and long-term biosafety studies are needed to clarify the proposed mechanism.
Jia-Jie Zheng, Kang Wang, Hao Xu et al.· International Journal of Nan...· 0 citations
Cryogenic 3D-printed Gel-OCS scaffold incorporating PCA/Cu2+/ε-PL-functionalized chitosan microspheres provides a single-step, customizable platform that combines robust mechanical properties with multi-modal therapeutic functionalities and highlights a novel therapeutic strategy for bone defect regeneration.
Jialing Zhuang, Shunyu Chen, Xiufeng Xiao· International Journal of Bio...· 1 citation
The developed scaffold showed higher cell viability value than control groups than control groups, and confirmed cells proliferation potential of the scaffold at prolonged times, and future studies should explore in vivo performance and long-term functionality of the scaffold.
Ali Khalaji, Soheila Zare, Faranak Aghaz et al.· Scientific Reports· 0 citations
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