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Review Jul 2026

Advances in engineering microalgae for heterologous terpenoid synthesis: A review.

Terpenoids are a class of natural products widely distributed in living organisms, with isoprene as their fundamental structural unit. However, traditional plant extraction and chemical synthesis methods are often limited by low product purity, difficult separation, and complex synthetic steps, making it challenging to...

Yue-Li Yuan, Jv-Liang Dai, Ling Xiao et al. · 0 citations
Review Jul 2026

Metabolic engineering strategies: utilizing different microbial strains and advanced technologies for the synthesis of high-valued terpenoids

Artificial intelligence (AI) and machine learning (ML) have emerged as powerful tools for metabolic engineering by enabling pathway prediction, metabolic flux optimization, enzyme engineering, and identification of bottlenecks throughout terpenoid biosynthesis.

Aakash Kamalesan, K. Kumar, Bharathi Nathan et al. · 0 citations
Review Open access Aug 2026

Research progress on biosynthesis and regulation of monoterpenoid compounds

This review summarizes recent advances in monoterpenoid biosynthesis, multilevel regulation, and heterologous production, with particular emphasis on major bottlenecks and optimization strategies for sustainable and efficient biomanufacturing.

Jun-Chi Zhang, Jiale Cui, Shang Li et al. · 0 citations
Review Aug 2026

Metabolic engineering of Candida yeasts for biotechnological applications.

This review systematically summarize recent progress in the metabolic engineering of Candida species as microbial cell factories, with particular emphasis on expanding genetic toolkits, utilizting renewable and non-conventional carbon sources, and biosynthesizing high-value compounds.

Xin-Yue Li, Qi Wang, Hang-Ming Zhang et al. · 0 citations
Review Open access Jul 2026

A Review of Plant-Derived Diterpenoid Biosynthesis: From Structural Scaffold Diversity and Lineage-Associated Distribution to Enzyme Mining and Discovery Strategies

It is proposed that scaffold enrichment in specific evolutionary lineages, when integrated with enzyme family expansion and functional divergence, may provide a complementary framework for prioritizing candidate tailoring enzymes.

Yalan Zhao, Mengyao Li, Shasha Zuo et al. · 0 citations

Discovery of new natural products from Actinobacteria using Cas12a-directed cloning

This research demonstrates the efficacy of a genome-led approach to drug discovery, which has successfully translated genomic data into tangible chemical matter, functionally characterised previously cryptic BGCs, and contributed a novel class of antibiotics to the global pipeline for combating infectious diseases.

Jing Da · 0 citations

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