TL;DR
Insight is provided into IRES-mediated translation of Δ160p53, which can be considered a novel target for cancer treatment and its role in cancer regulation.
Restoration of ΔNp63 expression mitigated the epidermal defects in Mettl16‐deficient mice and uncovered a novel METTL16‐m6A‐IGF2BP2‐ΔNp63 regulatory axis governing epidermal development, providing insights into the etiology of ectodermal dysplasias.
Findings prove that SYVN1 could promote the malignant characteristics of A549 cells by modulating the GATA3/NRP1 axis and that targeting SYVN1 could represent a promising therapeutic approach for treating lung cancer.
This review summarizes current knowledge regarding the molecular biology of TTP and HuR, emphasizing their opposing functions in mRNA metabolism and cancer progression; discusses mechanisms regulating their expression, localization, phosphorylation, and RNA-binding activity; analyze cancer-specific evidence; and examin...
It is demonstrated that NOP2 promotes LUAD progression by regulating FKBP4 expression, potentially through m5C methylation, thereby highlighting the NOP2/FKBP4 axis as a potential therapeutic target.
Clinically, high expression of eIF4A1, p70S6K, and TCF7L2 correlates with unfavorable prognosis in GC patients, and findings highlight eIF4A1 as a key regulator of stemness and metastasis through a novel translational feedback mechanism, suggesting potential therapeutic targeting to disrupt tumor progression.
Both in vitro assays and in vivo models confirmed that silencing ZNF695 dramatically suppresses CRC cell proliferation, migration, and invasion, while concurrently impeding tumor progression.
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