TL;DR
A model in which mRNA modifications act combinatorially to regulate mRNA homeostasis in plants is supported, including advances in profiling technologies, single-base resolution methods, and nanopore direct RNA sequencing.
The molecular mechanisms by which m6A regulates both coding and noncoding RNAs in HCC are summarized, the functional roles of key m6A regulators in hepatocarcinogenesis are highlighted, and the therapeutic potential of targeting the m6A machinery in HCC is discussed.
It is argued that while epitranscriptomics represents a compelling regulatory axis in cancer cell death, advancing the field will require integrative, high-resolution, and functionally precise approaches to move beyond correlative frameworks toward mechanistic and clinically actionable insights.
N nanopore direct RNA sequencing on zebrafish embryos across MZT is employed to resolve the interplay between m6A deposition, mRNA clearance, and poly(A) tail length dynamics at single-molecule resolution, and defines the single-molecule logic by which m6A modifications shape transcript fate during vertebrate MZT.
GLORI sequencing is applied to generate single-base resolution transcriptome-wide m6A maps in seven bacterial species to provide a quantitative atlas of bacterial m6A and establish a foundation for understanding its regulatory and evolutionary roles.
This study identifies the direct coordination of translation suppression and transcriptome reprogramming through m6A during the ISR, and shows that mRNA stabilization, not transcription activation, explains much of the transcriptome response during the ISR.
This review summarizes key RNA modifications and regulating RBPs with a specific emphasis on how dysregulation can lead to cancers.
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