This study identifies the direct coordination of translation suppression and transcriptome reprogramming through m6A during the ISR, and shows that mRNA stabilization, not transcription activation, explains much of the transcriptome response during the ISR.
Together, the findings establish hY3 as a ribosome-bound regulator of translation and stress responses, positioning it as a determinant of cell fate under metabolic stress.
DCP2, encoding a major mRNA decapping enzyme, is identified as a previously unrecognized ISR-induced transcript and it is shown that translational induction of DCP2 depends on an overlapping ORF whose conserved 3′ region, corresponding to a ribosome pausing site, acts as a potent inhibitory element.
This work shows that RNAPII is degraded during many types of cellular stresses, and redistribution is vital for cell survival, as degradation blockage resulted in the loss of RNAPII from low GC promoters and compromised stress response from disrupted cell adhesion to increased apoptosis.
Hansong Qi, Kang-Hsin Chen, Ning Liu et al.· Science Advances· 0 citations
A model in which mRNA modifications act combinatorially to regulate mRNA homeostasis in plants is supported, including advances in profiling technologies, single-base resolution methods, and nanopore direct RNA sequencing.
Thi Tuyet Suong Ha, S. Park, Dong-Hoon Jeong· Journal of Plant Biology· 0 citations
GCN2 is established as a major sensor mediating the early hepatic response to SAA deprivation, and a transcriptional program essential for maintaining amino acid homeostasis is defined, highlighting a coordinated adaptive response to acute SAA deprivation.
Valérie Carraro, M. Cherpaz, L. Longechamp et al.· Journal of Molecular Biology· 0 citations
In cells recovering from proteotoxic stress, inhibition of SUMO conjugation led to sustained activation of Heat Shock Factor 1 (HSF1) and SUMOylation of HSF1 as a central regulatory node for restoration of proteostasis, highlighting the critical role of SUMO signaling in regulating the dynamics of a molecular condensat...
S. Mueller, Upayan Patra, Svenja Kuska et al.· 0 citations
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