Targeting NMD has the potential to open new avenues for precision cancer therapy by revealing the previously unrealized immunogenic potential of tumors and bridging the gap between RNA biology and cancer immunotherapy.
The CRISPR strategy shows compelling evidence as a therapeutic approach targeting PE in cancer and other human diseases as well as the preferential advantages of CRISPR over the antisense technology recently developed targeting the PE of EZH2.
Overall, the findings suggest that TA is not a universal response to loss-of-function mutations in yeast, and the ability to resist specific transcriptomic ruptures would thus rely mostly on the general robustness of genetic networks.
Marzena Marszałek, W. Babik, R. Korona et al.· Molecular biology and evolut...· 0 citations
This work identified that NMD inhibition boosted neoantigen expression and presentation by tumor cells and increased T cell recognition, thus enhancing overall tumor immunogenicity and further improving immunotherapy efficacy in vivo, uncovering a novel TMB-dependent tractable vulnerability for this devastating disease...
Lucia A. Torres-Fernández, V. Boehm, Joel Kaufmann et al.· Molecular Cancer· 0 citations
Nonsense-mediated decay (NMD) is a vital RNA surveillance mechanism in eukaryotic cells that ensures mRNA quality and regulates gene expression. NMD targets mRNAs with premature translation-termination codons to prevent the production of potentially harmful truncated proteins. But NMD is also involved in modulating the...
Rafaela Lacerda, Miguel Carvalho, L. Romão· Journal of Molecular Biology· 1 citation
This review integrates current understanding of the biological origins, immunological barriers, target classes of splicing neoantigens, and the technologies that enable their advancement in cancer immunotherapy to produce two major classes of immunotherapeutic targets.
Mu-Tian Tang, H. L. Grimes, Nathan Salomonis· Frontiers in Immunology· 0 citations
This study provides mechanistic insight into how m6A couples with an exonuclease in R-loop clearance and genome maintenance and uncovers a druggable epitranscriptional machinery that constrains the innate immune response and enables SCC immune evasion.
Jieyou Zhang, Kaiwen Bao, Yayan Hou et al.· Molecules and Cells· 0 citations
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