TL;DR
Molecular docking results provided a molecular basis for the conjugate's interaction with target proteins (PDB IDs: 4LFU and 4TQX), suggesting its potential as a quorum-sensing modulator.
In bacterial-induced mouse models of epidermal and keratitis infections, cHH8-6 effectively reduces the bacterial count at the infection site with negligible in vivo toxicity, and due to its unique mechanism, cHH8-6 is less likely to induce bacterial resistance compared to clinical antibiotics.
Overall, BS3 was identified as a potential lead compound for further optimization as an antimicrobial agent and demonstrated concentration-dependent cytotoxicity with acceptable cell viability at lower concentrations.
Findings highlight haloarene-decorated tetrahydropyridine derivatives as promising dual-action candidates with potential to combat both bacterial and malarial infections.
4-pentenoic acid showed broad-spectrum activity against 21 strains of pathogenic bacteria, and the combination of 4-pentenoic acid with antibiotics exerted additive antibacterial effects, providing theoretical and experimental basis for the development of new food preservatives and antibacterial agents.
The experimental and computational findings suggest that cFP is a promising antimicrobial lead and warrant further mechanistic and translational investigation.
The results identify SH1 as a previously uncharacterised antibacterial agent active against MRSA and support the anthraquinone–DLC pharmacophore as a membrane-active scaffold warranting further structural optimisation.
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