Review

Stage V sporulation protein G as a global regulator of biofilm formation and virulence in Staphylococcus species: molecular mechanisms and therapeutic potential

Abirami Karthikeyan A. Javaid G. N. A. Charway Nazia Tabassum Tae-Hee Kim Young-Mog Kim Won-Kyo Jung Fazlurrahman Khan

Jul 2026 · World Journal of Microbiology & Biotechnology · Vol 42 · 0 citations · 72 references

Medicine

TL;DR

This review highlights SpoVG’s function in Staphylococcus, including its regulation of the expression of the adhesion factor gene sasC and the thermonuclease, which enables SpoVG to act as a molecular rheostat that influences biofilm formation and reduces acute virulence in response to environmental signals.

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