Pentoxifylline targets TLR4/MyD88/NF-κB signaling to ameliorate neuroinflammation and metabolic dysfunction in a rat model of chronic hypoperfusion-induced vascular cognitive impairment

Xiaohan Wang Bingchuan Xie Xiaoyang Yuan Jiaying Rong Xiaojing Lv Qingying Ma Li Shen Bing Han

Jul 2026 · Metabolic brain disease · Vol 41 · 0 citations · 37 references

Medicine

TL;DR

Pentoxifylline concurrently mitigates hypoperfusion-associated neuroinflammation, neuronal injury, and glucose hypometabolism via inhibition of the TLR4/MyD88/NF-κB axis, supporting PTX as a readily translatable candidate for early VCI intervention.

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