TL;DR
It is indicated that combining A-domain substrate prediction with genome mining is an effective strategy for discovering NRPs in Aspergillus, expanding the understanding of their biosynthetic potential.
PA1216, a putative methyltransferase embedded within an NRPS BGC in Pseudomonas aeruginosa strain PAO1 is characterized and a platform for characterizing cryptic gene clusters within secondary metabolic pathways is established for characterizing cryptic gene clusters within secondary metabolic pathways.
An alkaliphilic strain of Streptomyces S9 was isolated and taxonomically characterised through multilocus sequence analysis (MLSA) using Streptomyces-specific primers, indicating its genetic potential to biosynthesise aromatic polyketides.
A successful case study is presented demonstrating that combining KAS III-targeted genome mining with heterologous expression is a viable approach for discovering non-acetate-primed aromatic polyketides.
Findings indicate that Pseudoduganella sp.
Elucidating natural products encoded by cryptic biosynthetic gene clusters (BGCs) in agriculturally important biocontrol fungi such as Trichoderma afroharzianum T22 (ThT22) could lead to the discovery of new compounds that may be explored as potential agrochemicals. Herein, we discovered new lipopeptide natural product...
Findings suggest that strain D18 possesses adaptive strategies for survival in deep-sea environments and highlight its potential as a source of novel secondary metabolites.
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