Skip to content

Proximal Causal Learning under Unmeasured Confounding

Oct 2026 · 0 citations · 32 references
Computer Science

TL;DR

PCL-U is proposed, a framework that learns proxy variables directly from observed covariates and uses neural encoders to decompose covariates into treatment-inducing, outcome-inducing, and shared proxies, guided by minimax mutual information objectives and obtains causal estimates through a practical moment-based risk function.

Abstract

Estimating treatment effects from observational data typically relies on the No Unmeasured Confounding Assumption (NUCA), which rarely holds in practice. Proximal causal learning (PCL) addresses unmeasured confounding via proxy variables, yet existing methods require the proxy variables to be pre-specified. Thus, we propose PCL-U, a framework that learns proxy variables directly from observed covariates. PCL-U uses neural encoders to decompose covariates into treatment-inducing, outcome-inducing, and shared proxies, guided by minimax mutual information objectives, and obtains causal estimates through a practical moment-based risk function. Experiments on benchmarks show that PCL-U matches or outperforms existing baselines. Besides, there are two types of synthetic datasets with varying dimensions and confounding strengths that illustrate that our method maintains stable estimation accuracy.

View source

Similar papers

Proximal Balancing for Causal Effect Estimation under Unmeasured Confounding

Estimating causal effects from observational data is central to science and policy, but the effects are not identified when confounders are unmeasured. Proximal causal inference addresses this problem with proxies of the unmeasured confounders. However, existing proxy-based approaches either designate proxy roles and s...

Yong-Han Jung · 0 citations
Preprint Oct 2026

ProximalFM: Amortized Proximal Causal Inference under Hidden Confounding

Standard causal identification methods often assume no unmeasured confounding and can fail when relevant confounders are unobserved. Proximal causal inference instead uses proxy variables to identify effects under hidden confounding. However, nonparametric proximal estimation can be challenging in practice: recovering...

Christoph Müller, Ayub Kharel, Alex Luedtke et al. · 0 citations
Preprint Oct 2026

Proximal Causal Inference for Time Series from N-of-1Mobile Device Data

Unmeasured confounding challenges causal inference in intensive longitudinal studies, potentially biasing treatment effect estimates. The proximal causal inference (PCI) framework offers a promising approach to identification using proxies or negative control variables in the presence of hidden confounding bias. While...

Fan-Yu Cui, Charlotte R. Fowler, Xiao-Xuan Cai et al. · 0 citations

UvA-DARE (Digital

Maximilian Ilse, P. Forré, Max Welling et al. · 0 citations

UvA-DARE (Digital

A novel causal reduction method is proposed that replaces an arbitrary number of possibly high-dimensional latent confounders with a single latent confounder that lives in the same space as the treatment variable without changing the observational and interventional distributions entailed by the causal model.

Maximilian Ilse, P. Forré, Max Welling et al. · 0 citations
Oct 2026

Heterogeneous Treatment Effect Estimation with Distribution Shift and Unmeasured Confounding

Heterogeneous treatment effect (HTE) estimation is vital for understanding how treatment effects vary across individuals or subgroups. Recently, numerous HTE models, such as balancing methods and instrumental variable (IV) methods, have been developed to eliminate confounding bias from both observed variables and unmea...

Wen-Yang Liu, Yu-Ling Zhang, An-Peng Wu et al. · 0 citations

Related blog posts

Microsoft Research Blog Nov 3, 2026

Learn the rules: The hacker mindset

Research Manager Mike Walker reflects on a career spanning hacker culture, cybersecurity, and AI, sharing lessons about trust, teamwork, leadership, and why solving difficult problems requires curiosity, judgment, agility—and an understanding of the rules. The post Learn the rules: The hacker mindset appeared first on Microsoft Research.

Google DeepMind Blog Nov 3, 2026

Agentic cheminformatics with Google Antigravity

Learn how Google Antigravity and our Cheminformatics Skills accelerate drug discovery workflows, search compounds, and propose novel rigidified macrocycles.

We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.