Clinical Significance and Changes in Levels of Serum BDNF, mBDNF, AQP4, proBDNF, and GSK3β in Individuals Diagnosed With Bipolar Disorder: A Cross‐Sectional Study
Aug 2026· Health Science Reports· Vol 9· 0 citations· 42 references
Medicine
Abstract
Bipolar disorder (BD) is a severe mood disorder with unclear pathogenesis and limited diagnostic biomarkers. This study aimed to evaluate serum levels of BDNF, mBDNF, AQP4, proBDNF, and GSK3β between BD patients and healthy controls, and to preliminarily explore their potential clinical significance.
GBA1 variants increase neuropsychiatric vulnerability in Parkinson's disease (PD). In a multicenter cohort of 234 PD patients (78 GBA-PD, 156 nonGBA-PD), we investigated how GBA1 genotype and sex relate to depression. REM sleep behavior disorder was associated with depression in GBA-PD, while sex, cognition, and motor...
P. Mitrotti, M. Avenali, C. Artusi et al.· npj Parkinson's Disease· 0 citations
Abstract Background and aims Recent translational and clinical research emphasise the concept of interacting neurochemical disruptions as a ground for the development of psychosis. At the same time, literature highlighted neurostructural and functional alterations in ASD. However, evidence linking biochemical markers t...
C. Bonelli, L. Palego, B. Nardi et al.· World Journal of Biological...· 0 citations
The biological distinction between first-episode psychosis (FEP) and chronic schizophrenia remains unclear. This study investigated a panel of non-canonical serum biomarkers related to neurodegeneration, neuroinflammation, and neurotrophic signaling across these clinical stages. In a cross-sectional design, serum conce...
V. Zakurazhnaya, Y. Zorkina, O. Abramova et al.· BMC Psychiatry· 0 citations
This study evaluated whether circulating concentrations of vasoactive intestinal peptide, interleukin‐1β (IL‐1β), and tumor necrosis factor‐alpha (TNF‐α) differed according to the presence of anxiety and depressive symptoms among individuals with PD.
Liang-Yu Li, Xiao-Yang Jia, Ying-Chang Shi et al.· Brain and Behavior· 0 citations
To investigate whether neuromuscular fatigue and anxiety are associated with a peripheral biological signature involving inflammation, oxidative stress, mitochondrial homeostasis, neurotrophic support, and neuronal/glial injury markers in treatment‐naïve patients with relapsing‐remitting multiple sclerosis (RRMS).
Amanda V. Steckert, Keli Dias Feltrin, Luiz Fernando Silva Rodrigues et al.· Brain and Behavior· 0 citations
It is demonstrated that decreased serum BDNF levels are associated with the presence and symptom severity of anxiety disorders, and the Val66Met polymorphism does not appear to be a primary determinant of serum BDNF levels in this population, suggesting that other genetic or environmental factors may be involved.
Dicle Yilmaz Uyanik, Merve Şahin Can, O. Baykan et al.· Molecular Biology Reports· 0 citations
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