TL;DR
These exploratory findings indicate that hypertension-associated epigenetic changes are captured by multi-generational epigenetic clocks and may implicate inflammation-related pathways, warranting confirmation in longitudinal studies.
Men with cardiometabolic disturbances exhibit accelerated epigenetic aging and distinct DNA methylation signatures associated with cardiometabolic burden, suggesting candidate biomarkers measurable in minimally invasive blood samples that may assist in early risk stratification and monitoring of disease progression in...
This EWAS of plasma homocysteine in a Korean cohort—one of the largest population-based homocysteine EWAS reported in an East Asian population to date—highlights three imprinted genomic domains, including L3MBTL1 and PEG3, which are robust to one-carbon-biomarker and NNAT adjustment.
This work constructed a heterogeneous stacked ensemble survival model based on DNAm data obtained from the Framingham Heart Study and constructed a survival prediction model based on the fusion of five complementary survival models by means of a neural network meta-learner.
Findings reveal specific gut taxa as hypothesis-generating candidates for mechanistic follow-up, rather than as individual-level diagnostic markers, in relation to biological aging pace independent of chronological age.
These five metabolic signatures of epigenetic age acceleration (EAA) exhibited significant associations with aging‐related phenotypes including higher disease risk, poorer health status, and adverse clinical indicators including Gallstones, chronic kidney disease, and hepatitis.
Findings reveal novel genetic contributors to melatonin regulation and establish their putative causal relationship with hypertension.
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