This study offers a comprehensive eQTL map and reveals causal chains of “variant-gene-phenotype” for HAA-related traits, which provides new insights into potential regulatory mechanisms and targets for prevention and treatment of altitude sickness.
Chenghui Zhao, Jia-Wei Guan, Jun-Hua Liu et al.· Communications Biology· 0 citations
These exploratory findings indicate that hypertension-associated epigenetic changes are captured by multi-generational epigenetic clocks and may implicate inflammation-related pathways, warranting confirmation in longitudinal studies.
Jangho Lee, S. Park, Jin-Taek Hwang et al.· GeroScience· 0 citations
To investigate the causal relevance of melatonin metabolism, which provides the biological basis for circulating melatonin levels, to specific depression symptom subtypes, we performed a targeted systematic review of melatonin metabolism pathways in the human brain and liver. Using two-sample Mendelian randomization (M...
Yuan-Bi Wang, Wen Wen, Han-Sheng Chen et al.· Journal of Affective Disorde...· 0 citations
The findings refine the genetic architecture of lipid traits and nominate candidate genes and regulatory variants for future studies of lipid-related cardiometabolic disease.
Sung-Ji Moon, Young Jun Park, Jaeyong Choi et al.· Metabolism: Clinical and Exp...· 0 citations
A lipidome-wide GWAS of 830 lipid species in 2,287 Hispanic/Latino participants and predictive modeling across omics layers provided a genetic landscape of lipid metabolism in a highly burdened population and highlights the challenges in predicting lipid abundance.
Wanying Zhu, Hung-Hsin Chen, H. Highland et al.· HGG advances· 0 citations
Findings suggest that the g.-809C allele decreases IDO2 transcription by reducing CLOCK binding affinity, thereby potentially affecting IDO2-associated tryptophan/melatonin metabolism and increasing melatonin levels, which may contribute to photoperiodic responses in sheep.
Xunping Jiang, Shaxuan Chi, Xiaodong Wang et al.· Animal Genetics· 0 citations
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