Dopamine Receptor D2 gene Polymorphisms rs2005313, rs4274224, and rs4938019 in Pakistani Patients with Schizophrenia:a Diagnostic Tool for Schizophrenia
Aug 2026· Journal of Molecular Neuroscience· Vol 76· 0 citations· 43 references
Medicine
TL;DR
The research identified highly significant associations across multiple inheritance models, validating the technical robustness of the findings, and establish DRD2 intronic polymorphisms as critical determinants of schizophrenia risk.
HTR2A variation was associated with early risperidone-clozapine response, with consistent signals under the recessive model and at the haplotype level, and haplotype analysis may provide a more robust approach for detecting pharmacogenetic contributions to treatment response.
Nurul Hidayah, M. Ikawati, M. M. Amin et al.· Pharmacogenetics & Genomics· 0 citations
The A allele was found to be the most common variant of rs10741657 in the CYP2R1 gene and was not a risk for the susceptibility to vitamin D deficiency, and the inheritance genetic models suggested no association with vitamin D deficiency.
Abdur Rauf, Asifa Majeed· JPMA. The Journal of the Pak...· 0 citations
This study is the first to demonstrate that the TGFA rs3732248 polymorphism is significantly associated with PCOS susceptibility in an Iranian population, providing novel genetic evidence supporting a role for TGFA in PCOS pathogenesis and warrant replication in larger independent cohorts.
F. Keykha, M. Mohammadi, Marzieh Ghasemi et al.· BMC Women's Health· 0 citations
The present study indicated the variant-trait association of DAT1 40 bp 3′ UTR VNTR with psychiatric conditions in the Pakistani population, suggesting disorder-specific and allele-dependent effects of DAT1 variation.
A. Hashmi, Raees Ahmed Dharejo, R. Qamar et al.· Molecular Biology Reports· 0 citations
Both NT5C2 rs11191580 and DRD2 − 141C Ins/Del polymorphisms were associated with schizophrenia susceptibility in the Batak population but not with symptom severity.
Wijaya Taufik Tiji, Elmeida Effendy, M. M. Amin et al.· F1000Research· 0 citations
Genotype frequencies of the MIR155 rs767649, under codominant, dominant, recessive, and overdominant inheritance models, as well as allelic frequencies, showed no significant differences between PD patients and healthy controls, and the age at PD onset did not differ among the three MIR-155 rs767649 genotypes.
H. Alonso-Navarro, S. Ladera-Navarro, P. Ayuso et al.· International Journal of Mol...· 0 citations
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