DOES RS11191580 NT5C2 AND DRD2-141C INS/DEL POLYMOPRHIMSM AFFECT SCHIZOPHRENIA SYMPTOMS SEVERITY IN BATAK POPULATION
TL;DR
Both NT5C2 rs11191580 and DRD2 − 141C Ins/Del polymorphisms were associated with schizophrenia susceptibility in the Batak population but not with symptom severity.
Abstract
Introduction Schizophrenia is a highly heritable psychiatric disorder with a complex genetic architecture. Variants in NT5C2 and DRD2 have been implicated in schizophrenia susceptibility; however, their relationships with symptom severity and cognitive impairment remain inconsistent across different ethnic populations. This study investigated the association of NT5C2 rs11191580 and DRD2 − 141C Ins/Del polymorphisms with schizophrenia, psychopathology, and cognitive function in the Batak population of North Sumatra, Indonesia. Methods A hospital-based case–control study was conducted involving 50 Batak patients with schizophrenia and 50 ethnically matched healthy controls. Genotyping of NT5C2 rs11191580 and DRD2 − 141C Ins/Del polymorphisms was performed using polymerase chain reaction. Psychopathology was assessed using the Positive and Negative Syndrome Scale (PANSS). Results Significant differences in genotype distributions were observed between schizophrenia patients and healthy controls for NT5C2 rs11191580 (p = 0.022) and DRD2 − 141C Ins/Del (p < 0.001). Neither polymorphism was associated with PANSS severity categories or PANSS total and subscale scores (all p > 0.05). Discussion Both NT5C2 rs11191580 and DRD2 − 141C Ins/Del polymorphisms were associated with schizophrenia susceptibility in the Batak population but not with symptom severity.