Aug 2026· Planta· Vol 264· 0 citations· 68 references
Medicine
TL;DR
Structural similarities within the linker domain of different ABCB-type proteins revealed structural similarities within the linker domain, including the presence of [R/K-X-S/T] and [R/K-X-X-S/T] motifs, which are potential phosphorylation sites for kinases of the AGCVIII superfamily, and a phosphorylation-based regulatory mechanism is proposed for ABCB alkaloid transporters.
Cryo-electron microscopy structures of At ABCC2 provide new insights into the detoxi cation mechanism of At ABCC2 and highlight the potential for using ABCC transporters to develop herbicide-resistant crops.
An evolutionarily ancient regulatory module is uncovered that shapes the molecular organization and function of IE KEAs, advancing the understanding of plastid ion and pH homeostasis and plastid ribosome integrity.
Tobias Wunder, L. Holzner, Nikolay Manavski et al.· bioRxiv· 0 citations
It is becoming increasingly clear that large conformational changes in dimeric arrangements deserve attention, alongside other understudied areas like lipid interactions, nucleotide or N-terminal binding to the dimerization domains, and potential roles of the less described member SLC12A9.
Alexandra Náplavová, P. Nissen, R. K. Flygaard· Journal of Structural Biolog...· 0 citations
This study demonstrates that CsAlaDC originated from CsSDC via gene duplication followed by functional specialization, and elucidate the evolutionary trajectory of CsAlaDC and provides mechanistic insights into the molecular regulation of theanine biosynthesis in tea plants.
Hui Zhou, Pei-Xian Bai, Yong-Xin Wang et al.· Horticulture Research· 0 citations
Computational modelling, subcellular localisation, and functional assays across the DUP240 gene family identify Ktd1 as the central effector of the Dup240 family in toxin defence and provide a mechanistic framework for understanding Dup240 regulation.
Hatwan Nadir, Alex Pembery, K. Laidlaw et al.· bioRxiv· 0 citations
The study underscores hydrophobic interactions as key determinant of AOX function proposing valine as potential site for in-vitro mutagenesis to modulate AOX-mediated stress responses and exploring strategies for improving plant stress tolerance.
Varsha Venugopalan, Rajesh Parsanathan, D. Challabathula et al.· Journal of Biomolecular Stru...· 0 citations
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