System CpxRA Negatively Regulates the Locus of Enterocyte Effacement of Enterohemorrhagic Escherichia coli Involving 32 σ and Lon protease RETRACTED: The Two-Component

Tracy L. Raivio Jorge A. Girón M. A. de la Cruz Jason Morgan Miguel A. Ares Jorge A Yañez-Santos J. Riordan

· 0 citations · 81 references

TL;DR

The Galleria mellonella model of infection was used and the effect of the loss of the cpx and lon genes in EHEC’s ability to kill the larvae was found, suggesting that virulence in the G. mellonella model is T3SS independent and that CpxA modulates virulence through a yet unknown EHEC-speciﬁc factor.

Semantic Scholar

View source

Similar papers

Open access Sep 2026

Regulation and Characterization of the Cex system of enteric pathogens: a pathway for the lipidation and secretion of noncanoncial bacterial lipoproteins

CexE is an outer membrane lipoprotein of enterotoxigenic Escherichia coli (ETEC); one of the most prevalent etiological agents of diarrheal disease. Homologs of CexE are present in enteroaggregative E. coli, Citrobacter rodentium, and other enteropathogens. We have previously shown that expression of CexE is dependent...

Z. Rivas, Kacey M. Talbot, Griffin P. Carter et al. · bioRxiv · 0 citations

Aug 2026

Comprehensive Genomic Analysis of the pO157 Plasmid in Enterohemorrhagic Escherichia coli O157:H7 Reveals Non-synonymous Variation in Virulence Factors

Comparative pan-genomic and structural analyses indicate that pO157 maintains a highly conserved genomic organization while preserving limited sequence variability among virulence-associated genes.

L. Y. Smith, P. Farace, J. S. García et al. · Current Microbiology · 0 citations

Open access Jul 2026

Modulation of BarA/UvrY Two-Component System Expression in Escherichia coli Induced by Ceftazidime Treatment

The dynamic expression of UPEC's stress response mechanisms are emphasized and the central role of Bar/UvrY in modulating pathoadaptive mechanisms under antibiotic stress is outlined.

Ali Hazim Jabbar, M. Flayyih · Iraqi Journal of Science · 0 citations

Open access Sep 2026

Contrasting regulation of the ecp common pilus operon in Citrobacter rodentium: essential roles of a distal element and IHF even in the absence of H-NS

The Escherichia coli common pilus (ECP) is a chaperone–usher pilus widely distributed in E. coli and other enterobacteria, where it mediates adhesion, biofilm formation, and colonization. Citrobacter rodentium, a surrogate model for the human attaching-and-effacing pathogens enteropathogenic and enterohemorrhagic E. co...

María I. Isidro-Coxca, Verónica I. Martínez-Santos, Andrés Escalera-Maurer et al. · Archives of Microbiology · 0 citations

Open access Aug 2026

The (p)ppGpp Synthetase RelA Contributes to Virulence, Competition Capability and Antibiotic Resistance of Avian Pathogenic Escherichia coli

It is indicated that relA plays a key role in APEC virulence, antibiotic resistance, and membrane homeostasis, and could provide a theoretical basis for targeting the stringent response as a potential strategy to control avian colibacillosis.

Jiangang Hu, Dossêh Jean Apôtre Afayibo, Chang Liu et al. · Microorganisms · 0 citations

Open access Aug 2026

Phage-encoded sRNA counteracts xenogeneic silencing in pathogenic E. coli

Horizontal gene transfer introduces foreign DNA that can disrupt cellular processes and is therefore subject to xenogeneic silencing by nucleoid-associated proteins such as H-NS and Hha. In Enterohaemorrhagic Escherichia coli (EHEC), prophages make up a large fraction of the accessory genome and encode many virulence f...

Pranita Poudyal, Brandon M. Sy, Daniel G. Mediati et al. · PLoS Pathogens · 0 citations