The structure and regulatory circuitry of PrfA are addressed, then antivirulence strategies targeting this protein using natural compounds, synthetic inhibitors, and nanomaterial-based approaches are surveyed.
GltC contributes to the coordination of nitrogen metabolism, oxidative stress adaptation, and bacterial fitness during L. monocytogenes infection, which is critical for identifying new strategies to limit bacterial survival in the host.
S. Ogunleye, Monzur Chowdhury, H. Abdelhamed· Microbiology spectrum· 0 citations
It is demonstrated that A. flavus encodes two hsfA copies, whose knockdown or expression of a dominant-negative variant abrogates spore germination, a prerequisite for fungal development and colonization, and established HsfA as a pivotal regulator of A. flavus virulence and uncovered a novel HSF regulatory pathway.
X. Nie, Guo-Long Zhu, Bei Qin et al.· Virulence· 0 citations
A regulatory pathway is identified that enables the pathogen to adapt to its different hosts, and it is shown that this pathway can be chemically inhibited.
Alexandre Baillez, Amélie Dewitte, F. Pierre et al.· Nature Communications· 0 citations
YgeP plays a central role in APEC pathogenesis by balancing two infection strategies: motility-mediated dissemination and colonization, and biofilm-mediated attachment and tolerance, and negatively regulates key virulence traits during the early stages of infection.
Weiyang Su, Zhe Li, Siqi Feng et al.· Veterinary Microbiology· 0 citations
Light is shed on regulatory cascades and a mechanistic basis is provided for understanding how clinically acquired T6SS clusters may be integrated into existing virulence networks is provided.
Yi-Zhou Zhang, T. Ye, Jie Deng et al.· International Journal of Bio...· 0 citations
The genome-wide analysis revealed extensive FtcR-binding sites throughout the B. melitensis 16M genome, including the identification of glnB as a novel target, which suggests FtcR plays a direct role in modulating nitrogen, carbon, and energy metabolism under prolonged nutrient starvation.
Yi-Dan Zhang, Yu Zhang, Sheng-Nan Song et al.· Microorganisms· 0 citations
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