Post-translational modifications of KRAS: from molecular regulation to therapeutic targeting

Abstract

: The rat sarcoma virus (RAS) proteins are small GTPases that regulate cell signaling and are frequently mutated in human cancers. Their activity is mainly controlled by cycling between guanosine diphosphate (GDP)-bound and guanosine triphosphate (GTP)-bound states, which is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs)