Objective: Pathological invasion influences patient prognosis in lung adenocarcinoma (LUAD); however, diagnosis is often associated with high interobserver variability because non-lepidic adenocarcinoma (NLA) and cancer-related fibrosis (CRF) are intricately mixed, and CRF contains both invasive and non-invasive components. In this study, to enable quantitative and reproducible diagnosis of areas showing high intratumoral heterogeneity, we proposed an artificial intelligence (AI)-based analysis distinguishing between NLA and CRF. This approach could reduce interobserver variability in prognostic prediction and help examine the different biological meanings of NLA and CRF. Methods: To clarify the physiological structure of lung parenchyma, we used elastin staining specimens. CRF and NLA were separately annotated in the first cohort (n = 35) and used for supervised learning. The AI then analyzed whole non-lepidic areas in the second cohort (n = 188); we then examined the relationship between clinicopathological features and the AI analysis. Results: For the first cohort, the accuracy was 89.2% on average. For the second cohort, groups with high CRF ratios (>50%) in the AI analysis showed a statistical correlation with types B-C in Noguchi's classification (p < 0.001), grades 1-2 in the WHO grading system (p = 0.018), and a higher 5-year disease-free survival (DFS) rate (85.7% vs. 69.4%, p = 0.006). In groups with a low CRF ratio (n = 111), a central distribution of CRF was associated with a lower DFS rate (41.2% vs. 74.5%, p = 0.001). Conclusion: The AI engine for distinguishing between NLA and CRF enabled prognostic prediction of LUAD with reduced interobserver variability. It may also be useful for examining the biological significance of NLA and CRF.
Various recent Artificial Intelligence (AI) system failures, some of which have made the global headlines, have highlighted issues in these systems. These failures have resulted in calls for more ethical AI systems that better take into account their effects on various stakeholders. However, implementing AI ethics into practice is still an on-going challenge. High-level guidelines for doing so exist, devised by governments and private organizations alike, but lack practicality for developers. To address this issue, in this paper, we present a method for implementing AI ethics. The method, ECCOLA, has been iteratively developed using a cyclical action design research approach. The method aims at making the high-level AI ethics principles more practical, making it possible for developers to more easily implement them in practice.
Ville Vakkuri, Kai-Kristian Kemell, P. Abrahamsson· EUROMICRO Conference on Soft...· 64 citations· ⚡6
Progress in the field of artificial intelligence has been accelerating rapidly in the past two decades. Various autonomous systems from purely digital ones to autonomous vehicles are being developed and deployed out on the field. As these systems exert a growing impact on society, ethics in relation to artificial intelligence and autonomous systems have recently seen growing attention among the academia. However, the current literature on the topic has focused almost exclusively on theory and more specifically on conceptualization in the area. To widen the body of knowledge in the area, we conduct an empirical study on the current state of practice in artificial intelligence ethics. We do so by means of a multiple case study of five case companies, the results of which indicate a gap between research and practice in the area. Based on our findings we propose ways to tackle the gap.
Ville Vakkuri, Kai-Kristian Kemell, Joni Kultanen et al.· arXiv.org· 56 citations· ⚡6
The growing influence and decision-making capacities of Autonomous systems and Artificial Intelligence in our lives force us to consider the values embedded in these systems. But how ethics should be implemented into these systems? In this study, the solution is seen on philosophical conceptualization as a framework to form practical implementation model for ethics of AI. To take the first steps on conceptualization main concepts used on the field needs to be identified. A keyword based Systematic Mapping Study (SMS) on the keywords used in AI and ethics was conducted to help in identifying, defying and comparing main concepts used in current AI ethics discourse. Out of 1062 papers retrieved SMS discovered 37 re-occurring keywords in 83 academic papers. We suggest that the focus on finding keywords is the first step in guiding and providing direction for future research in the AI ethics field.
Ville Vakkuri, P. Abrahamsson· International Conference on...· 39 citations· ⚡2
Artificial Intelligence (AI) systems exert a growing influence on our society. As they become more ubiquitous, their potential negative impacts also become evident through various real-world incidents. Following such early incidents, academic and public discussion on AI ethics has highlighted the need for implementing ethics in AI system development. However, little currently exists in the way of frameworks for understanding the practical implementation of AI ethics. In this paper, we discuss a research framework for implementing AI ethics in industrial settings. The framework presents a starting point for empirical studies into AI ethics but is still being developed further based on its practical utilization.
Ville Vakkuri, Kai-Kristian Kemell, P. Abrahamsson· Conference on Technology Eth...· 27 citations· ⚡3
There is a rapidly increasing amount of Artificial Intelligence (AI) systems developed in recent years, with much expectation on its capacity of innovation and business value generation. However, the promised value of AI systems in specific business contexts might not be understood, and further integrated into the development processes. We wanted to understand how software engineering processes and practices can be applied to develop AI systems in a fast-faced, business-driven manner. As the first step, we explored contextual factors of AI development and the connections between AI developments to business opportunities. We conducted 12 semi-structured interviews in seven companies in Brazil, Norway and Southeast Asia. Our investigation revealed different types of AI systems and different AI development approaches. However, it is common that business opportunities involving with AI systems are not validated and there is lack of business-driven metrics that guide the development of AI systems. The findings have implications for future research on business-driven AI development and supporting tools and practices.
Anh Nguyen-Duc, Ingrid Sundbø, E. Nascimento et al.· International Conference on...· 20 citations· ⚡1
Investigating how experienced developers use agents in building software, including their motivations, strategies, task suitability, and sentiments finds that while experienced developers value agents as a productivity boost, they retain their agency in software design and implementation out of insistence on fundamental software quality attributes.
