Open access
Induced degradation of Ufd1 reveals regulation of cohesin by the VCP/p97Ufd1-Npl4 complex
Daniella Munro
M. Reinders
Aikaterini Pravi
J. van den Boom
Pinki Gahlot
E. Isaakova
Caio A. B. Oliveira
Dominik Boos
Petra Beli
H. Meyer
Medicine
Abstract
The p97-Ufd1-Npl4 complex targets ubiquitylated RAD21 to extract a subpopulation of cohesion specifically in S-phase to facilitate DNA replication and suppress replication-associated DNA damage.