Apolipoprotein C-III (apoC-III) has emerged as a pivotal therapeutic target for lipid-lowering therapies, particularly for hypertriglyceridemia. However, its broader implications in the pathogenesis of atherosclerosis remain to be fully elucidated. ApoC-III is extensively studied for its classical role in modulating lipoprotein lipase activity; nevertheless, recent evidence highlights its multifaceted mechanisms involving the regulation of remnant cholesterol clearance, low-density lipoprotein subfraction transformation, high-density lipoprotein functionality, and inflammasome activation. Meanwhile, the emergence of novel APOC3 gene-edited models beyond murine systems has provided indispensable perspectives for deciphering the complex links between apoC-III and atherogenesis. Therefore, this review aims to comprehensively summarize the translational research surrounding apoC-III, from its central function in lipoprotein metabolism to its critical lipoprotein lipase-independent effects, offering a promising outlook for the clinical management of atherosclerotic cardiovascular disease.
Some claim that especially in the field of agile software development the research lags years behind of the practice. In this paper, we characterize the status and main challenges for research on agile software development, and propose a preliminary roadmap, focusing on providing more empirical research, primarily on e...
Torgeir Dingsøyr, T. Dybå, P. Abrahamsson· Agile Conference· 92 citations· ⚡7
The results indicate that software developers are a slightly happy population, but the need for limiting the unhappiness of developers remains, and 219 factors representing causes of unhappiness while developing software are identified.
D. Graziotin, Fabian Fagerholm, Xiaofeng Wang et al.· International Conference on...· 84 citations· ⚡6
This study investigates how Lean internal startup facilitates software product innovation in large companies and identifies its enablers and inhibitors, and shows the potential of the method-in-action framework to investigate the Lean startup approach in non-startup context.
Henry Edison, Nina M. Smørsgård, Xiaofeng Wang et al.· Journal of Systems and Softw...· 78 citations· ⚡6
The goal is to not only refine the accuracy of the LLM-based tool but also to underscore its potential in streamlining the software development lifecycle through proactive code improvement and education.
Z. Rasheed, Malik Abdul Sami, Muhammad Waseem et al.· arXiv.org· 62 citations· ⚡3
Agile methods continue to gain popularity. In particular, the Scrum method appears to be on the verge of becoming a de-facto standard in the industry, leading the so called Agile movement. While there are success stories and recommendations, there is little scientifically valid evidence of the challenges in the adoptio...
A. Marchenko, P. Abrahamsson· Agile Conference· 59 citations· ⚡11
A comprehensive overview of how enhanced sampling methods are reshaping the field, with a particular focus on the data-driven construction of collective variables, is provided.
Kai Zhu, Enrico Trizio, Jintu Zhang et al.· Chemical Reviews· 58 citations
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
