TL;DR
In general, epigenetic regulation provides a new conceptual framework for understanding TEC dysfunction in DKD and provides a potential direction for the development of precision therapeutic strategies.
A narrative review elaborates the closed-loop crosstalk between mitochondrial metabolism and epigenetics in tubular injury, highlights the therapeutic prospect of targeting this bidirectional regulatory axis, and provides novel theoretical evidence for revealing DKD pathogenesis and developing targeted intervention reg...
This review systematically examines the mechanisms of metabolic reprogramming in different renal cell types and highlights their contribution to renal injury, highlighting the ability of natural products to confer renal protection by modulating key regulatory nodes of metabolic reprogramming.
Multi-omics integration and spatial transcriptomics hold promise for individualized and mechanism-guided interventions to halt diabetic kidney disease progression and propose precision strategies targeting mitochondrial homeostasis, ferroptosis inhibition, glycolytic blockade in immune cells, and multimodal therapies.
This review integrates current insights into the complex interplay among metabolic stress, mitochondrial injury, and cellular senescence in Diabetic cardiomyopathy and highlights promising directions for mechanism-based interventions aimed at combating diabetic cardiac remodeling.
The cellular and molecular mechanisms of EndMT relevant to CKD are summarized, key regulatory pathways and pathway crosstalk are highlighted, and emerging pharmacological approaches to limit EndMT, preserve microvascular integrity, and attenuate renal fibrogenesis are discussed.
This review summarizes the principal epigenetic changes involved in HSC activation, initiation/progression of liver fibrosis, and discusses recent interventions designed to modulate these epigenetic changes.
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