Jul 2026· Cardiovascular Drugs and Therapy· 0 citations· 78 references
Medicine
TL;DR
This review integrates current insights into the complex interplay among metabolic stress, mitochondrial injury, and cellular senescence in Diabetic cardiomyopathy and highlights promising directions for mechanism-based interventions aimed at combating diabetic cardiac remodeling.
It is demonstrated that CMA is suppressed in the aging heart, which promotes collagen overproduction in fibroblasts, whereas enhancing CMA activity ameliorates fibrosis and diastolic dysfunction and establishes a BHB-HCAR2-CMA-SHMT2 regulatory axis as a critical mechanism driving aging-related cardiac fibrosis.
The molecular mechanisms and key signaling pathways linking autophagy to PAH, with emphasis on PTEN-induced kinase 1 (PINK1)/Parkin-mediated mitophagy and the AMP-activated protein kinase (AMPK)/mechanistic target of rapamycin (mTOR) energy-sensing axis are summarized.
Miao Li, Li-Mei Piao· Journal of Cardiovascular De...· 0 citations
A conceptual framework in which CaMKII connects molecular stress signaling to age-related cardiac disease phenotypes is proposed and current evidence remains limited by the predominance of animal and cell-based studies, limited direct evidence from older human myocardium without overt cardiovascular disease, incomplete...
Ting Li, Yuan Chen, Bei Xu et al.· Artery Research· 0 citations
Cellular senescence contributes to the pathology of diabetic kidney disease (DKD). Besides, mitochondrial dysfunction and cellular senescence are closely associated pathological processes that may influence one another during kidney injury progression. Dapagliflozin has demonstrated its renal protective benefits indepe...
Xin Tong, Bin Wang, Fen-Fei Gao et al.· Biochemical Pharmacology· 0 citations
In general, epigenetic regulation provides a new conceptual framework for understanding TEC dysfunction in DKD and provides a potential direction for the development of precision therapeutic strategies.
Hanxue Li, Meng-Meng Ma, Qiuyue Ren et al.· International Urology and Ne...· 0 citations
Current knowledge regarding the molecular and cellular mechanisms driving senescence in hematopoietic stem cells and circulating blood-cells and how these mechanisms affect specific blood-cell populations leading to altered immune function, impaired tissue homeostasis, and persistent inflammatory activation are summari...
K. Gioti, Maria Trapali, Irene Belouka et al.· Cells· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
