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Factors associated with abnormal screening for autism spectrum disorder among Extremely Preterm Children.

Jul 2026 · Journal of Perinatology · 0 citations · 41 references
Medicine

TL;DR

Children born EPT have increased positive ASDS and it is important to assess their socioemotional development early and pos-ASDS risk factors to facilitate prompt intervention.

Abstract

Objective

To investigate positive results on a screening instrument for autism spectrum disorder (pos-ASDS) and associated neonatal and early developmental risk factors in school-age children born extremely preterm (EPT). STUDY

Design

Researchers assessed 380 EPT children (GA 24 to <28 weeks) at 6-7 years-of-age using the Social Communication Questionnaire (SCQ). Pos-ASDS was defined as an SCQ score ≥15. Logistic regression examined independent associations of perinatal factors and 18-22 months behavior and cognitive scores with pos-ASDS.

Results

Fourteen % of the children scored ≥ 15 in the ASDS (SCQ). Risk factors included male sex, lower birth weight, severe retinopathy of prematurity, motor/sensory impairments, lower cognitive scores, poorer emotional competence, and more behavioral problems at 18-22 months. Neonatal MRI and cranial ultrasound findings were not significantly different.

Conclusion

Children born EPT have increased positive ASDS. It is important to assess their socioemotional development early and pos-ASDS risk factors to facilitate prompt intervention.

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