Beyond Lectures: Implementing Project-Based Learning (PjBL) to Enhance Engagement and Skill Development in Biochemistry

INTRODUCTION Traditionally, biochemistry and molecular biology teaching has relied heavily on lecture-based instruction, a method increasingly criticized for promoting superficial learning and limited student engagement. However, the use of constructivist methodologies has reshaped the landscape, encouraging approaches that achieve proficiency in these subjects, critical thinking skills and the integration of interdisciplinary knowledge.  

Objectives

To expose students to real-world challenges, stimulate entrepreneurial thinking, and foster the development of soft skills essential for success in competitive scientific environments, PjBL was implemented in Biochemistry and Molecular Biology courses across seven undergraduate programs at the UNIFESP.  

Methods

STRATEGY In 2025, the initiative involved 262 students organized into groups of four to six members. The project was conducted as a collaborative, semester-long activity and incorporated multiple formative assessment components throughout its development. In this activity, students produced content on a subject of their own choosing for scientific dissemination, examining the task from different perspectives using a variety of resources and managing the information they collect. Different means of presentation can be used but using appropriate language.  

Results

The findings indicate that 50% of students considered PjBL important for learning biochemistry and molecular biology, and 65% subsequently engaged in extension activities. Additionally, student perception questionnaires revealed that the most significantly developed skills were teamwork, responsibility, collaboration, and conceptual understanding. In contrast, language adequation, reference selection, and final project delivery were perceived as the most challenging aspects. Students identified iterative feedback during project development and the process of selecting scientific references as the most valuable steps of the experience.  

Conclusion

Overall, these results suggest that PjBL not only increases students’ interest in biochemistry but also enhances communication, project management, and collaborative skills. Therefore, this methodology represents a promising strategy for preparing students for professional careers and lifelong learning success.