SENP7 mediates deSUMOylation and deubiquitination of SP1 to promote lung adenocarcinoma progression and chemoresistance

Abstract

Highlights • SENP7 protein is markedly expressed in LUAD, with a strong correlation to disease progression and adverse patient prognoses.• The depletion of SENP7 substantially impedes LUAD progression in both in vitro and in vivo.• SP1 is a bona fide target of SENP7, with SENP7-mediated deSUMOylation, deubiquitination, and stabilization of SP1 being essential for LUAD development and chemoresistance.