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Author

Qing Huang

3 papers indexed here

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Open access Sep 2026

SENP7 mediates deSUMOylation and deubiquitination of SP1 to promote lung adenocarcinoma progression and chemoresistance

Highlights • SENP7 protein is markedly expressed in LUAD, with a strong correlation to disease progression and adverse patient prognoses.• The depletion of SENP7 substantially impedes LUAD progression in both in vitro and in vivo.• SP1 is a bona fide target of SENP7, with SENP7-mediated deSUMOylation, deubiquitination,...

Zhen Zhang, Qing Huang, Zi-Mei Peng et al. · 0 citations
Open access Jul 2026

Metabolic reprogramming via SIRT2-deficient microglial large extracellular vesicles ameliorates alzheimer's pathology.

LEVs are identified as a critical vesicle subtype mediating the effects of SIRT2 knockdown and support a cell-free therapeutic strategy for AD centered on EVs-driven metabolic reprogramming of microglia.

Xiaolu Tang, Rui Chen, Jiawei Xing et al. · 0 citations

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