Multi-carbapenemase-producing Klebsiella pneumoniae: Genomic characterization and In Vitro evaluation of cefiderocol and novel β-lactam/β-lactamase inhibitor combinations

Genomic Characterisation of Carbapenem-Resistant Klebsiella pneumoniae and Enterobacter hormaechei Clinical Isolates from Nigeria: Evidence of Resistance, Virulence, and Putative Plasmid-Mediated Gene Sharing

Describing clinically relevant resistance and virulence determinants in three purposively selected carbapenem-resistant Enterobacterales from Nigerian tertiary-care hospitals identifies possible plasmid-mediated gene sharing.

Triple carbapenemase-producing Klebsiella pneumoniae ST6668 resistant to novel β-lactam/β-lactamase inhibitor combinations and cefiderocol, Northern Italy, 2025.

Klebsiella pneumoniae ST6668 has recently emerged in Northern Italy, but data on its resistance architecture remain limited. We identified a K. pneumoniae ST6668 (KNVO1) strain co-producing NDM-1, VIM-1 and OXA-48 carbapenemases, via multiple megaplasmids, from an elderly hospitalized patient who experienced clinical d...

The Evolving Clonal, Plasmid-Mediated Resistome, Virulome and Therapeutic Landscape of Carbapenem-Resistant Klebsiella pneumoniae in Oman

Background: Carbapenem-resistant Klebsiella pneumoniae (CRKP) increasingly combines high-risk clonal expansion, mobile resistance platforms and limited treatment options. We investigated the genomic epidemiology, resistance and virulence architecture, plasmid backbones, and therapeutic vulnerabilities of CRKP circulati...

Beyond Carbapenemases: Chromosomal Resistance Mechanisms and Carbapenemase Type Determine Susceptibility to Novel β-Lactam/β-Lactamase Inhibitor Combinations and Cefiderocol in Carbapenem-Resistant Pseudomonas aeruginosa from China

Background: β-lactam/β-lactamase inhibitor combinations (BL/BLIs) and siderophore cephalosporin serve as critical polymyxin alternatives for carbapenem-resistant Pseudomonas aeruginosa (CRPA). However, systematic multicenter clinical data from China and the resistance mechanisms underlying non-susceptibility to these a...

Molecular characterization of carbapenem resistance and hypervirulence determinants of Klebsiella pneumoniae circulating in a tertiary hospital in Cyprus

Molecular Characterization and Resistance Gene Co-occurrence in Carbapenem-Resistant Klebsiella peumoniae from a Bangkok Tertiary Hospital, Thailand.

INTRODUCTION Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a significant global health concern due to its high morbidity and mortality rates and limited treatment options. We investigated the molecular characteristics and co-occurrence of resistance genes in CRKP isolates from a tertiary hospital in Bangkok, Tha...