Review
Open access
Advances in γδ T Cells: Cutaneous Biology and Therapeutic Potential for Skin Neoplasms
Si-Mo Du
Anika Jallorina
Toru Yoshino
Ling-Yu Bao
Han Bao
V. Chang
Henry K. Wong
D. Chan
Stephen K. Richardson
M. Lee-Wong
Medicine
Abstract
γδ T cells represent an increasingly important subset of T lymphocytes in the immune response to cancer and as a platform for novel immunotherapies. The aim of this review is to synthesize recent insights into the biology and advances in therapeutic applications of γδ T cells in cutaneous malignancies, especially melanoma, within a framework of tumor immunology and recent clinical research.