Large language model-generated patterns for epidemiological modeling: a multi-benchmark evaluation framework

Abstract

Representing individual-level behavioral heterogeneity is challenging in epidemiological modeling, particularly when empirical behavioral data are sparse. We assess the potential of large language model (LLM)-generated behavioral outputs in addressing this challenge, using hepatitis C virus-related behaviors among people who inject drugs as a case study. Correspondence with epidemiological patterns was evaluated using external benchmarks: literature-informed association directions, correlations from an agent-based model (ABM), and survey associations. Across three LLMs, unconditional directional recovery across 28 retained literature-informed associations was 46-68%, compared with 82-93% agreement when LLMs were directly asked to classify the same associations. Mean absolute differences from ABM and survey correlation patterns were 0.11-0.13 and 0.15-0.18, respectively. Together, these findings show partial alignment between LLM-generated behavioral relationships and epidemiological evidence, despite higher knowledge-probe agreement. More systematic evaluation is needed before incorporating LLM-generated behavioral outputs into epidemiological models that simulate transmission dynamics.