Jul 2026· Food and Chemical Toxicology· Vol 217, pp.
116306
· 0 citations· 33 references
Medicine
Abstract
As a persistent organic pollutant (POP), 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) can accumulate through the food chain and enter the human body. Most existing studies have focused on short-term toxicity, with insufficient understanding of its chronic toxicity. In this study, a 6-month chronic exposure model was established in C3H/He mice via intragastric gavage. Hematological analysis and biochemistry tests were conducted, and organ coefficients along with histopathological changes were analyzed. Additionally, liver ultrasound elastography was assessed. The results showed that BDE-47 could significantly reduce renal index, serum levels of albumin (ALB), triglycerides (TG), and urea (UREA), increase uric acid (UA) levels, cause a dose-dependent decrease in liver elasticity, and lead to hepatic steatosis, atrophy of seminal vesicle epithelium, shedding of spermatogenic cells, and infiltration of splenic macrophages. Collectively, this study has confirmed that BDE-47 has significant chronic toxicity to mammals, providing a new basis for subsequent toxicological research and safety risk evaluation.
Background: This study investigated the acute oral toxicity of the widely used VIVA PLUS® detergent in BALB/c mice to address significant public health concerns regarding accidental ingestion.Methods: Four groups of 5 mice of both sexes, averaging 21-28 g, were administered oral graded doses (1000, 2000, and 5000 mg/kg...
Unknown authors· Journal of the Nigerian Infe...· 0 citations
Bisphenol A (BPA) is a pervasive industrial environmental pollutant widely used in chemical manufacturing, leading to continuous human and animal exposure through food and resource contamination. While its broad multi-organ toxicities are well-documented, its sub-acute destructive impact on mammalian respiratory histol...
M. Hussein· Scientific Progress & In...· 0 citations
Bisphenol A (BPA) and its analogs are widely recognized for their use in industry and plastic manufacturing. Consequently, humans and animals are continually exposed to various substances in their daily lives. This review evaluates the hepatic toxicity of BPA and its analogs in mice and rats, with particular emphasis o...
S. Bagdatli, M. Canik, Gizem Gencay et al.· Journal of Applied Toxicolog...· 0 citations
Nonylphenol (NP) is an alkylphenol environmental contaminant with endocrine-disrupting activity and potential hepatotoxicity. However, the molecular responses associated with different NP exposure durations remain insufficiently characterized. In this study, male Kunming mice were exposed to NP through drinking water a...
Xiao-Hang Yang, Yao-Dong Zhang, Jin-Long Liu et al.· Ecotoxicology and Environmen...· 0 citations
To explore the protective effects of selenium nanoparticles (SeNPs) against renal, hepatic, and reproductive toxicity induced by aflatoxin, male Sprague-Dawley rats (n = 36), 3 months old and weighing 162-233 g (198.17 ± 2.64 g), were equally divided into control, SeNPs, aflatoxin, and SeNPs-aflatoxin groups. Blood and...
Mona H. Soliman, Mohamed S. Aly, H. I. Shafey et al.· Reproductive Biology· 0 citations
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