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#artificial intelligence Preprint Open access

LabOPBench: A Multimodal Benchmark for Evidence-Grounded Laboratory Decision Making

Jingyuan Li Yujie Liu Yijie Dai Xiaoyu Yuan Nian Ran Huajie Niu Ming Zhu Shuwen Zhao Chenxi Li Fenghao Lu Jiahao Li Xinyu Gu Zhe Liu Long Xu Wenlong Zhang Bo Zhang Lei Bai Peiyu Zhang Minting Pan Weinan Zhang Dongzhan Zhou
Oct 2026
Artificial Intelligence

Abstract

Laboratory experiments involve more than following predefined protocols; they require adaptive decision-making as the experimental state changes. Existing scientific benchmarks rarely assess such evidence-based decisions in laboratory settings. Here we present LabOPBench, a multimodal benchmark of 756 expert-authored, independently reviewed questions in organic synthesis and materials science. Each item pairs laboratory evidence with procedural context and an open-ended judgment, evaluated using a question-specific scoring rubric. Eight multimodal models obtain overall normalized scores of 28.8-45.8%, leaving substantial room for improvement. On a controlled 100-question subset, the strongest models outperform undergraduate participants on average but remain below the average performance of PhD participants. Expert analysis of responses from the three leading models identifies Evidence Misreading and Evidence-Decision Conflict as the dominant error patterns. These results reveal that current models still struggle to turn multimodal perception into reliable laboratory decision-making.

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