OmicsBench: a long-horizon multi-turn benchmark of AI agents on research-study-scale bioinformatics

Abstract

Computational biologists increasingly delegate substantial analyses to AI agents in long-horizon, multi-turn sessions, yet most benchmarks of agents' bioinformatics capabilities pose a single short task with a single-shot prompt. We present OmicsBench, a long-horizon, multi-turn bioinformatics benchmark for AI agents. Each of its 97 tasks links dependent subtasks into a directed acyclic graph, for 662 underlying subtasks in all. Each subtask is posed as one user turn and graded deterministically against an answer key, with optional in-context feedback on incorrect answers. Across 12 models on three harnesses, the slowest agent averages 3.6 hours per task, and no combination comes near saturating the benchmark, with mean scores of 0.43 to 0.57 out of a possible 1 without in-context feedback and 0.54 to 0.67 with it. Multi-turn evaluation also uncovers behavior that single-shot prompts cannot, as agents score lower on subtasks that depend on earlier subtasks, and in-context feedback helps agents recover some of that loss. Because deterministic scoring gives no qualitative account of how an agent failed, we also introduce an unsupervised failure mode discovery pipeline that describes, embeds, and clusters agents' failed attempts to surface emergent failure modes. Applied to OmicsBench, this pipeline exposes qualitative shortcomings in how agents carry out bioinformatics analyses, ranging from agents applying their own statistical filters in place of the specified ones to agents writing whole answers from memory.